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[5] [6] Tamoxifen treatment is also used for the treatment of osteoporosis and blood lipids in postmenopausal women. Adverse effects of tamoxifen include hot flashes and an increase in the risk of developing endometrial cancer compared to women of similar age. [6] [4]
Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14] Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. [14] Common side effects include irregular periods, weight loss, and hot flashes. [14]
Tamoxifen is also thought to lower the risk of breast cancer in those who have a predisposition or at risk. [9] Tamoxifen may be used in pre and postmenopausal women. [10] Toremifene is a similar SERM drug to tamoxifen, but is less common and only approved for treatment of metastatic cancer. Toremifene is generally prescribed once tamoxifen is ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
After menopause the vaginal epithelium changes and becomes a few layers thick. [18] Many of the signs and symptoms that accompany menopause occur in atrophic vaginitis. [3] The earliest symptoms of atrophic vaginitis may be decreased vaginal lubrication, while other symptoms may appear later. [14] Genitourinary symptoms include dryness [3] [19 ...
After reading through it, she started doing more research on her own. Julie read about hot flashes, night sweats, and brain fog . “But out of all the symptoms listed, the one my brain focused on ...
At menopause, estrogen production in the ovaries ceases, but other tissues continue to produce estrogen through the action of the enzyme aromatase on androgens produced by the adrenal glands. When the action of aromatase is blocked, estrogen levels in post-menopausal women can drop to extremely low levels, causing growth arrest and/or apoptosis ...
Another study looked at the effects of adjuvant therapies like letrozole in women of different ages, both premenopausal and postmenopausal. Pritchard found that letrozole favorably impacted women in both groups but was overall more effective in premenopausal women who had been previously treated with tamoxifen.
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