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  2. Fenfluramine - Wikipedia

    en.wikipedia.org/wiki/Fenfluramine

    Fenfluramine is a substituted amphetamine and is also known as 3-trifluoromethyl-N ... [40] The FDA granted approval of Fintepla to Zogenix, Inc. [7] On ...

  3. Trifluoromethylation - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethylation

    S-(trifluoromethyl)dibenzothiophenium tetrafluoroborate is a commercially available and known trifluoromethylation reagent based on the same principle first documented in 1990. [ 64 ] [ 65 ] In this type of compound sulfur has been replaced by oxygen , selenium and tellurium .

  4. Mefloquine - Wikipedia

    en.wikipedia.org/wiki/Mefloquine

    FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. [5] The drug was first approved in Switzerland in 1984 by Hoffmann-LaRoche, [32] who brought it to market with the name Lariam. [33] However, mefloquine was not approved by the FDA for prophylactic use until 1989.

  5. Tolrestat - Wikipedia

    en.wikipedia.org/wiki/Tolrestat

    Tolrestat (AY-27773) is an aldose reductase inhibitor [1] which was approved for the control of certain diabetic complications. [2]While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval.

  6. Brilacidin - Wikipedia

    en.wikipedia.org/wiki/Brilacidin

    Brilacidin (formerly PMX-30063 [2]), an investigational new drug, is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs).

  7. Trifluoromethyl group - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethyl_group

    Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...

  8. Triflupromazine - Wikipedia

    en.wikipedia.org/wiki/Triflupromazine

    Triflupromazine (Vesprin) is an antipsychotic medication of the phenothiazine class. Among different effects of triflupromazine indication for use of this drug is severe emesis and severe hiccups.

  9. Flutamide - Wikipedia

    en.wikipedia.org/wiki/Flutamide

    Flutamide is the generic name of the drug and its INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name, BAN Tooltip British Approved Name, DCF Tooltip Dénomination Commune Française, and JAN Tooltip Japanese Accepted Name.