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The reagent was used in trifluoromethylation of a thiophenolate. S-(trifluoromethyl)dibenzothiophenium tetrafluoroborate is a commercially available and known trifluoromethylation reagent based on the same principle first documented in 1990. [64] [65] In this type of compound sulfur has been replaced by oxygen, selenium and tellurium.
The trifluoromethyl group occurs in certain pharmaceuticals, drugs, and abiotically synthesized natural fluorocarbon based compounds. The medicinal use of the trifloromethyl group dates from 1928, although research became more intense in the mid-1940s. [2]
Trifluoromethyldeschloroketamine (TFMDCK) is a designer drug from the arylcyclohexylamine family, which is presumed to have similar properties to ketamine, a ...
5-Trifluoromethyl-2-aminoindane (TAI) is a drug of the 2-aminoindane group with putative entactogenic effects. It functions as a selective serotonin releasing agent (SSRA). TAI is the aminoindane analogue of norfenfluramine and is approximately 50% as neurotoxic in comparison.
Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde. These compounds are derivatives of benzaldehyde with trifluoromethyl substituents. The CF 3 group enhances the electrophilicity of the formyl group and provides a label for analysis by fluorine-19 nuclear magnetic resonance spectroscopy.
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF 3) is an organosilicon compound with the formula CF 3 Si(CH 3) 3.It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.
Fenfluramine was an appetite suppressant which was used to treat obesity. [8] It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen. [8] In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome. [7] [51]
Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer. [9] [10] It is also used in the treatment of androgen-dependent conditions like acne, excessive hair growth, and high androgen levels in women. [11] It is taken by mouth, usually three times per day ...