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A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor. The repressor in turn binds to a gene's operator sequence (segment of DNA to which a transcription factor binds to regulate gene expression), thereby blocking transcription of that gene.
The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors.
Corepressor proteins also bind to the surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where L = leucine, I = isoleucine and X = any amino acid). [7] In addition, compressors bind preferentially to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor).
20185 Ensembl ENSG00000141027 ENSMUSG00000018501 UniProt O75376 Q60974 RefSeq (mRNA) NM_001190438 NM_001190440 NM_006311 NM_001252313 NM_011308 NM_177229 RefSeq (protein) NP_001177367 NP_001177369 NP_006302 n/a Location (UCSC) Chr 17: 16.03 – 16.22 Mb Chr 11: 62.21 – 62.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The nuclear receptor co-repressor 1 also known as thyroid ...
54880 71458 Ensembl ENSG00000183337 ENSMUSG00000040363 UniProt Q6W2J9 Q8CGN4 RefSeq (mRNA) NM_001123383 NM_001123384 NM_001123385 NM_001130139 NM_017745 NM_020926 NM_001168321 NM_029510 NM_175044 NM_175045 NM_175046 RefSeq (protein) NP_001116855 NP_001116856 NP_001116857 NP_060215 NP_001161793 NP_083786 NP_778209 NP_778210 NP_778211 Location (UCSC) Chr X: 40.05 – 40.18 Mb Chr X: 11.9 – 12. ...
Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene. [ 5 ] [ 6 ] Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.
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23186 217864 Ensembl ENSG00000089902 ENSMUSG00000037896 UniProt Q9UKL0 Q8CFE3 RefSeq (mRNA) NM_015156 NM_198023 RefSeq (protein) NP_055971 NP_932140 Location (UCSC) Chr 14: 102.59 – 102.73 Mb Chr 12: 111.01 – 111.08 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene. Function This gene ...