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Bicalutamide may cause sexual dysfunction, including decreased sex drive and erectile dysfunction. [8] However, the rates of these side effects with bicalutamide monotherapy are very low. [ 8 ] In the EPC trial, at 7.4 years follow-up, the rates of decreased libido and impotence were only 3.6% and 9.3% in the 150 mg/day bicalutamide monotherapy ...
This story was reviewed by Mike Bohl, MD. In the ‘80s, researchers set out to test a medication called sildenafil citrate for treating high blood pressure and angina (chest pain) from heart disease.
In addition to a "hard flaccid" penis, patients may also experience erectile dysfunction (difficulty achieving or maintaining an erection; painful or tight erections; penis does not fill up completely when getting an erection; no morning erections; no nocturnal erections; no spontaneous erections; painful nocturnal erections), sensory changes ...
Diseases are also common causes of erectile dysfunction. Diseases such as cardiovascular disease, multiple sclerosis, kidney failure, vascular disease, and spinal cord injury can cause erectile dysfunction. [10] Cardiovascular disease can decrease blood flow to penile tissues, making it difficult to develop or maintain an erection.
Endothelial dysfunction is a risk factor that is specifically associated with erectile dysfunction. [13] Past family medical history of sexual dysfunction disorders are also a risk factor for development. Sociocultural factors may also contribute to sexual problems, such as personal, religious, or cultural beliefs about sex.
The term erectile dysfunction does not encompass other erection-related disorders, such as priapism. Treatment of ED encompasses addressing the underlying causes, lifestyle modification, and addressing psychosocial issues. [4] In many instances, medication-based therapies are used, specifically PDE5 inhibitors like sildenafil. [13]
Erection hardness (EH) is a key indicator of erectile dysfunction (ED) and is usually assessed through tactile methods. The Erection Hardness Score (EHS) is a simple, validated, self-reported tool that measures erection hardness on a 4-point scale: 0 (no enlargement), 1 (enlarged but not hard), 2 (hard but not for penetration), 3 (hard enough for penetration but not fully rigid), and 4 (fully ...
Cardiovascular side effects can include hypertension or hypotension from a vasovagal response, Raynaud's phenomenon (reduced blood flow to the hands and feet), and tachycardia (increased heart rate). [87] [79] [100] Sexual side effects in males may include erectile dysfunction, frequent erections, or prolonged erections. [87]