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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The U.S. Food and Drug Administration (FDA) has approved several medications for the treatment of ED, including: Sildenafil ... heart disease, heart attack or other cardiovascular condition should ...
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8]
Sildenafil, the active ingredient in Viagra, is actually used to treat a certain kind of high blood pressure in the lungs. ... including those used for high blood pressure and heart disease. While ...
Certain medications for heart disease If you experience severe side effects after using Viagra or other ED medication, it’s important to seek medical advice and assistance as soon as possible ...
The lab discovered that inhibiting phosphodiesterase type 5A(PDE5A), which degraded cyclic guanosine onophosphate (cGMP) and was inhibited by the drug sildenafil (Viagra®), blunted heart contractility from adrenergic stimuli in animal and human hearts, [28] [29] [30] and when chronically administered to animals, it improved their heart ...
Generic sildenafil (and brand-name Viagra) is a medication for the treatment of ED, Raynaud’s phenomenon, and pulmonary arterial hypertension. To understand how Viagra works, we need to look at ...
The Best ED Medication for Men: Pros & Cons of Top ED Pills. Over the last 25 years, (ED) medications like Viagra and Cialis have become common fixtures in bedrooms around the world.
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