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Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
Low blood pressure (hypotension) develops and rapidly leads to septic shock. The cyanosis of extremities can be extreme and the patient is very prostrated or comatose. In this form of meningococcal disease, meningitis generally does not occur.
In septic shock the blood flow in the microvasculature is abnormal with some capillaries underperfused and others with normal to high blood flow. [5] The endothelial cells lining the blood vessels become less responsive to vasoconstrictive agents, lose their glycocalyx (normal coating) and negative ionic charge, become leaky and cause extensive ...
Septic thrombophlebitis is characterized by a bacterial or fungal infection that coexists with venous thrombosis.Deep veins or superficial veins could be affected. Septic thrombophlebitis can manifest as anything from a harmless condition that affects a small area of superficial veins to serious systemic infections that cause shock and even death.
10 to 80% risk of death; [4] [6] These mortality rates (they are for a range of conditions along a spectrum: sepsis, severe sepsis, and septic shock) may be lower if treated aggressively and early, depending on the organism and disease, the patient's previous health, and the abilities of the treatment location and its staff: Frequency
[10] The next step in treating end organ damage due to septic shock is to identify the source of the infection and treat it. Broad-spectrum antibiotics can be started that will treat many potential bacteria before cultures grow the specific bacteria that is causing the infection. Once cultures identify the culprit of the infection, the ...
Septic shock begins as sepsis, which is “the body’s dysregulated response to infection,” says Dr. Justin Belsky, assistant professor of emergency medicine at Yale School of Medicine.
In septic patients, these clinical signs can also be seen in other proinflammatory conditions, such as trauma, burns, pancreatitis, etc. A follow-up conference, therefore, decided to define the patients with a documented or highly suspicious infection that results in a systemic inflammatory response as having sepsis. [ 18 ]