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The critical nerves affected are the phrenic nerve (which drives the diaphragm to inflate the lungs) and those that drive the muscles needed for swallowing. By destroying these nerves, this form of polio affects breathing, making it difficult or impossible for the patient to breathe without the support of a ventilator. It can lead to paralysis ...
Poliovirus is, however, strictly a human pathogen, and does not naturally infect any other species (although chimpanzees and Old World monkeys can be experimentally infected). [40] The CD155 gene appears to have been subject to positive selection. [41] The protein has several domains of which domain D1 contains the polio virus binding site.
A virus that affects nerves in the spinal cord or brain stem causes polio. ... Cutter Laboratories, had kept the live polio virus in hundreds of thousands of doses. In April 1955, over 400,000 ...
Neurotropic viruses that cause infection include Japanese Encephalitis, Venezuelan Equine Encephalitis, and California encephalitis viruses; polio, coxsackie, echo, mumps, measles, influenza and rabies, as well as diseases caused by members of the family Herpesviridae such as herpes simplex, varicella-zoster, Epstein–Barr, cytomegalovirus and HHV-6 viruses. [2]
Polio is “shorthand for poliomyelitis, a disease of the central nervous system caused by infection with poliovirus,” Dr. Richard Lloyd, professor of molecular virology and microbiology at ...
A few could contract meningitis if the polio virus attacks the covering of the spinal cord or brain. Polio is fatal for 2%-10% of those paralyzed or between 1 in 2,000 to 1 in 10,000 of those ...
David Bodian (15 May 1910 – 18 September 1992) was an American medical scientist at the Johns Hopkins University School of Medicine who worked in polio research. In the early 1940s he helped lay the groundwork for the eventual development of polio vaccines by combining neurological research with the study of the pathogenesis of polio.
Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring at about a 25–40% rate (latest data greater than 80%). They are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic attack.