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Non-specific immunity, or innate immunity, is the immune system with which you were born, made up of phagocytes and barriers. Phagocytosis , derived from the Greek words phagein , meaning to eat, kytos or cell, and “osis” meaning process, was first described by Élie Metchnikoff , who won the Nobel Prize 100 years ago.
The innate immune system or nonspecific immune system [1] is one of the two main immunity strategies in vertebrates (the other being the adaptive immune system). The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants , fungi , prokaryotes , and invertebrates (see Beyond vertebrates ).
The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.
Innate immune defenses are non-specific, meaning these systems respond to pathogens in a generic way. [19] This system does not confer long-lasting immunity against a pathogen. The innate immune system is the dominant system of host defense in most organisms, [2] and the only one in plants. [20]
Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
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This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, [13] and many pathogens have evolved methods to evade attacks by phagocytes. [14]