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In bioscience, translational research is a term often used interchangeably with translational medicine or translational science or bench to bedside. The adjective "translational" refers to the " translation " (the term derives from the Latin for "carrying over") of basic scientific findings in a laboratory setting into potential treatments for ...
Academy of Translational Medicine Professionals is working to advance the ongoing knowledge and skills for clinicians and scientific professionals at all levels. Academy's high quality, standard and ethical training and educational programs ensure that all clinical and scientific professionals achieve excellence in their respective fields.
These initial steps toward research on literary translation were collected in James S. Holmes' paper at the Third International Congress of Applied Linguistics held in Copenhagen in 1972. In that paper, "The name and nature of translation studies", Holmes asked for the consolidation of a separate discipline and proposed a classification of the ...
The most widely used definition of knowledge translation was published in 2000 by the Canadian Institutes of Health Research (CIHR): "Knowledge translation (KT) is defined as a dynamic and iterative process that includes synthesis, dissemination, exchange and ethically-sound application of knowledge to improve the health of Canadians, provide more effective health services and products and ...
The focus of translational neuroscience research is to investigate the molecular mechanisms for these disorders, and to investigate the mechanisms of drug delivery to treat these disorders, including an investigation into the impact of the blood-brain barrier on drug delivery, and the role of the body's immune system in neurodegenerative disorders.
There is some overlap with the related domain of clinical research informatics, but TRI is more concerned with enabling multi-disciplinary research to accelerate clinical outcomes, with clinical trials often being the natural step beyond translational research. Translational research as defined by the National Institutes of Health includes two ...
Binding of the cap by eIF4E is often considered the rate-limiting step of cap-dependent initiation, and the concentration of eIF4E is a regulatory nexus of translational control. Certain viruses cleave a portion of eIF4G that binds eIF4E, thus preventing cap-dependent translation to hijack the host machinery in favor of the viral (cap ...
Translational regulation refers to the control of the levels of protein synthesized from its mRNA. This regulation is vastly important to the cellular response to stressors, growth cues, and differentiation .