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All RMPs for COVID‑19 vaccines will be published on the EMA's website. [136] The EMA published guidance for developers of potential COVID‑19 vaccines on the clinical evidence to include in marketing authorization applications. [137] In November 2020, the CHMP started a rolling review of the Moderna vaccine for COVID‑19 known as mRNA-1273 ...
The potential emergence of a SARS-CoV-2 variant that is moderately or fully resistant to the antibody response elicited by the COVID-19 vaccines may necessitate modification of the vaccines. [333] The emergence of vaccine-resistant variants is more likely in a highly vaccinated population with uncontrolled transmission.
In contrast to other mRNA COVID-19 vaccines, such as those by Pfizer-BioNTech and Moderna, this vaccine primarily targets the SARS-CoV-2 receptor-binding domain of the spike protein, rather than the entire spike protein. [4] It is approved for Phase III trials in China, [5] Mexico, [6] Indonesia, [7] and Nepal. [8]
Coronavirus disease 2019, a contagious disease caused by SARS-CoV-2; COVID-19 pandemic, a coronavirus pandemic that began in December 2019 and ended in May 2023; Variants of SARS-CoV-2. SARS-CoV-2 Alpha variant, a variant of SARS-CoV-2 first identified in the United Kingdom in 2020
Researchers at the Precision Vaccine Program at Boston Children's Hospital and Harvard Medical School, in Boston, Massachusetts, in collaboration with Texas Children's Hospital Center for Vaccine Development and Baylor College of Medicine in Houston, Texas, undertook a screening process that compared multiple molecules head-to-head in different ...
In California as of July 31, 37% of seniors had received the updated COVID-19 vaccine for the 2023–24 season, as did 18.7% of those age 50 to 64, and 10.1% of the youngest adults.
The potential emergence of a SARS-CoV-2 variant that is moderately or fully resistant to the antibody response elicited by the COVID-19 vaccines may necessitate modification of the vaccines. [451] The emergence of vaccine-resistant variants is more likely in a highly vaccinated population with uncontrolled transmission. [ 452 ]
The Lambda variant, also known as lineage C.37, is a variant of SARS-CoV-2, the virus that causes COVID-19. [1] It was first detected in Peru in August 2020. [ 2 ] On 14 June 2021, the World Health Organization (WHO) named it Lambda variant [ 1 ] and designated it as a variant of interest . [ 3 ]
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