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Modern interest in vasopressors as a treatment for cardiac arrest stem mostly from canine studies performed in the 1960s by anesthesiologists Dr. John W. Pearson and Dr. Joseph Stafford Redding in which they demonstrated improved outcomes with the use of adjunct intracardiac epinephrine injection during resuscitation attempts after induced ...
Overall, calcium is not routinely used during cardiac arrest as it does not provide additional benefit (compared to non-use) and may even cause harm (poor neurologic outcomes). [ 114 ] Vasopressin overall does not improve or worsen outcomes compared to epinephrine. [ 82 ]
Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or even delay premature labor, among other things. These drugs can act through several mechanisms, such as directly activating postsynaptic receptors, blocking breakdown and reuptake of certain neurotransmitters, or stimulating production and release of catecholamines.
Another emergency that can lead to cardiac arrest, commotio cordis, is a disruption of heart rhythm after a blow to the area directly over the heart at a key time during a heartbeat cycle.
Epinephrine is used to treat a number of conditions, including cardiac arrest, anaphylaxis, and superficial bleeding. [25] It has been used historically for bronchospasm and low blood sugar, but newer treatments for these that are selective for β 2 adrenoceptors, such as salbutamol, are preferred. [citation needed]
CPR is used on people in cardiac arrest to oxygenate the blood and maintain a cardiac output to keep vital organs alive. Blood circulation and oxygenation are required to transport oxygen to the tissues. The physiology of CPR involves generating a pressure gradient between the arterial and venous vascular beds; CPR achieves this via multiple ...
Defibrillators mounted in many public buildings can save the life of someone in cardiac arrest, but they’re almost never used, a new study finds. According to research funded by the National ...
Timing the shock to the R wave prevents the delivery of the shock during the vulnerable period (or relative refractory period) of the cardiac cycle, which could induce ventricular fibrillation. If the patient is conscious, various drugs are often used to help sedate the patient and make the procedure more tolerable.