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Carcinoid syndrome is a paraneoplastic syndrome comprising the signs and symptoms that occur secondary to neuroendocrine tumors (formerly known as carcinoid tumors). [1] The syndrome is caused by neuroendocrine tumors most often found in the gut releasing biologically active substances into the blood causing symptoms such as flushing and diarrhea, and less frequently, heart failure, vomiting ...
Certain diseases such as neuroendocrine tumor of the small intestine (also known by the obsolete term carcinoid), which sometimes release large amounts of 5-hydroxytryptamine, commonly known as 5-HT or serotonin into the blood, may produce a characteristic pattern of mostly right-sided cardiac fibrosis which can be identified with echocardiography.
Potential causes of flushing in carcinoid syndrome include bradykinins, prostaglandins, tachykinins, substance P, and/or histamine, diarrhea, and heart problems. Because of serotonin's growth-promoting effect on cardiac myocytes, a serotonin-secreting carcinoid tumour may cause a tricuspid valve disease syndrome, due to the proliferation of ...
While the most common cause of pulmonary valve stenosis is congenital heart disease, it may also be due to a malignant carcinoid tumor. Both stenosis of the pulmonary artery and pulmonary valve stenosis are forms of pulmonic stenosis (nonvalvular and valvular, respectively) [6] but pulmonary valve stenosis accounts for 80% of pulmonic stenosis.
Enterochromaffin cells, which give rise to carcinoid tumors, were identified in 1897 by Nikolai Kulchitsky and their secretion of serotonin was established in 1953 [105] when the "flushing" effect of serotonin had become clinically recognized. Carcinoid heart disease was identified in 1952, and carcinoid fibrosis in 1961. [105]
Endocardial fibroelastosis (EFE) is a rare heart disorder usually occurring in children two years old and younger. [1] It may also be considered a reaction to stress, not necessarily a specific disease. [2] It should not be confused with endomyocardial fibrosis. [citation needed]
Apical four chamber ultrasound view of heart. Transthoracic echocardiography (TTE) uses ultrasonic waves for continuous heart chamber and blood movement visualization. It is the most commonly used imaging tool for diagnosing heart problems, as it allows non-invasive visualization of the heart and the blood flow through the heart, using a technique known as Doppler.
[2] [3] Thus the heart is restricted from stretching and filling with blood properly. It is the least common of the three original subtypes of cardiomyopathy: hypertrophic, dilated, and restrictive. [1] It should not be confused with constrictive pericarditis, a disease which presents similarly but is very different in treatment and prognosis. [1]
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