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Mannose (D-mannose) is used as a dietary supplement to prevent recurrent urinary tract infections (UTIs). [ 9 ] [ 10 ] As of 2022 [update] , one review found that taking mannose was as effective as antibiotics to prevent UTIs, [ 9 ] while another review found that clinical trial quality was too low to allow any conclusion about using D ...
GDP-mannose is produced from GTP and mannose-6-phosphate by the enzyme mannose-1-phosphate guanylyltransferase. The degradation of mannans (and many related forms of hemicellulose) has been well studied. The hydrolysis of the main mannan backbone is catalyzed by various enzymes including β-mannosidase, β-glucosidase, and β-mannase.
One way the most-recently discovered lectin pathway is activated is through mannose-binding lectin protein. MBL binds to carbohydrates (to be specific, D-mannose and L-fucose residues) found on the surfaces of many pathogens. For example, MBL has been shown to bind to: yeasts such as Candida albicans [19] [20] viruses such as HIV [21] and ...
Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides. This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism.
α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase. [3] [4]
The enzyme GDP-Mannose 4, 6-Dehydratase is in the lyase family of enzymes, specifically the hydro-lyases. Other names in use include guanosine 5'-diphosphate-D-mannose oxidoreductase, guanosine diphosphomannose oxidoreductase, guanosine diphosphomannose 4,6-dehydratase, GDP-D-mannose dehydratase, GDP-D-mannose 4,6-dehydratase, GMD, and GDP-mannose 4,6-hydro-lyase.
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