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However, the mutation causes accumulation of this protein within small to medium-sized blood vessels. [19] This disease often presents in early adulthood with migraines, stroke, mood disturbances, and cognitive deterioration. MRI shows white matter changes in the brain and also signs of repeated strokes. The diagnosis can be confirmed by gene ...
Microangiopathy (also known as microvascular disease, small vessel disease (SVD) or microvascular dysfunction) is a disease of the microvessels, small blood vessels in the microcirculation. [1] It can be contrasted to macroangiopathies such as atherosclerosis , where large and medium-sized arteries (e.g., aorta , carotid and coronary arteries ...
Vascular cognitive impairment [2] Brain atrophy from vascular dementia: Specialty: Psychiatry, neurology Symptoms: Cognitive impairment, short-term memory loss [3] Complications: Heart disease, loss of ability to care for self and interact, pneumonia [4] Causes: Conditions that impair blood vessels in the brain and therefore interfere with ...
Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy, [1] is a form of small-vessel vascular dementia caused by damage to the white brain matter. [2] White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. [3]
Moreover, focal narrowing of brain vessels and impairment of their ability to dilate in response to various stimuli may lead to a decreased cerebral blood flow and ultimately lacunar stroke. [ 11 ] Advanced age, chronic hypertension , smoking and diabetes mellitus are risk factors.
The most frequent presenting signs and symptoms of primary CNS vasculitis were focal neurological defecits (seen in 63% of cases), headaches (51%) and cognitive impairment (41%). [4] Other presenting symptoms include aphasia or other difficulties with speech (35-43%), ataxia , visual field deficits, acute or subacute encephalopathy (which may ...
Brain ischemia has been linked to a variety of diseases or abnormalities. Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population.
Lipohyalinosis is a cerebral small vessel disease affecting the small arteries, arterioles or capillaries in the brain.Originally defined by C. Miller Fisher as 'segmental arteriolar wall disorganisation', it is characterized by vessel wall thickening and a resultant reduction in luminal diameter.