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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications ... X-ray crystallographic structure of the 30S ...
Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. [2]
The structure of the kasugamycin-70S ribosome complex from Escherichia coli has been determined by X-ray crystallography at 3.5-A resolution. The drug binds within the messenger RNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA, which are sites of kasugamycin resistance.
While the main product produced by Streptomyces kanamyceticus is kanamycin A, additional products are also produced, including kanamycin B, kanamycin C, kanamycin D and kanamycin X. [18] The kanamycin biosynthetic pathway can be divided into two parts. The first part is common to several aminoglycoside antibiotics, such as butirosin and neomycin.
Streptomycin is an aminoglycoside. [3] It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death. [3] Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus. [5] [6] It is on the World Health Organization's List of Essential Medicines. [7]
Sisomicin is the most predictably active aminoglycoside against Gram-positive bacteria. [2] Like most other aminoglycosides, sisomicin is bactericidal for sensitive clinical isolates. The minimum bactericidal concentrations (MBC) have been found to be equivalent or very close to the minimum inhibitory concentrations (MIC). [ 3 ]
A small silver amulet discovered by archaeologists in Germany could transform our understanding of how Christianity spread under the Roman Empire, experts have said.
Isepamicin (isepamycin) is an aminoglycoside antibiotic. It was patented in 1973 and approved for medical use in 1988. [ 1 ] It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.