Search results
Results from the WOW.Com Content Network
Pyrimidine biosynthesis creates derivatives —like orotate, thymine, cytosine, and uracil— de novo from carbamoyl phosphate and aspartate. As is often the case with parent heterocyclic ring systems, the synthesis of pyrimidine is not that common and is usually performed by removing functional groups from derivatives.
Alloxan, sometimes referred to as alloxan monohydrate, is an organic compound with the formula OC(NHCO) 2 C(OH) 2.It is classified as a derivative of pyrimidine.The anhydrous derivative OC(NHCO) 2 CO is also known, as well as a dimeric derivative.
It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an amine group at position 4 and a keto group at position 2). The nucleoside of cytosine is cytidine. In Watson–Crick base pairing, it forms three hydrogen bonds with guanine.
Uracil is a common and naturally occurring pyrimidine derivative. [2] The name "uracil" was coined in 1885 by the German chemist Robert Behrend, who was attempting to synthesize derivatives of uric acid. [3]
Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together.It is water-soluble.Purine also gives its name to the wider class of molecules, purines, which include substituted purines and their tautomers.
Thiourea is building blocks to pyrimidine derivatives. Thus, thioureas condense with β-dicarbonyl compounds. [9] The amino group on the thiourea initially condenses with a carbonyl, followed by cyclization and tautomerization. Desulfurization delivers the pyrimidine. The pharmaceuticals thiobarbituric acid and sulfathiazole are prepared using ...
Similarly, the simple-ring structure of cytosine, uracil, and thymine is derived of pyrimidine, so those three bases are called the pyrimidine bases. [ 6 ] Each of the base pairs in a typical double- helix DNA comprises a purine and a pyrimidine: either an A paired with a T or a C paired with a G.
Synthesis of nucleosides involves the coupling of a nucleophilic, heterocyclic base with an electrophilic sugar. The silyl-Hilbert-Johnson (or Vorbrüggen) reaction, which employs silylated heterocyclic bases and electrophilic sugar derivatives in the presence of a Lewis acid, is the most common method for forming nucleosides in this manner.