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The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. [6] RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE protein subunits. [7] RhAG ...
The gene codes for the RhD protein on the red blood cell membrane. D− individuals who lack a functional RHD gene do not produce the D antigen and may be immunized by D+ blood. [citation needed] The D antigen is a dominant trait. If both of a child's parents are Rh negative, the child will definitely be Rh negative.
The RhD gene that codes for the RhD antigen is located on chromosome 1. This chromosome contains gene instructions for making proteins in the body. [3] RhD is a dominant gene, meaning that as long as at least one RhD gene is inherited from a single parent, the RhD antigen is expressed.
The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes.
The Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, [2] including both NF-κB and NFAT, among others.Some of these transcription factors appear to form multi-protein DNA-bound complexes. [3]
If she is negative for RhD protein expression and has not formed anti-D already, she is a candidate for RhoGam prophylaxis to prevent alloimmunization. If she is positive for anti-D antibodies, the pregnancy will be followed with monthly titers (levels) of the antibody to determine if any further intervention is needed.
Transmembrane protein 50A is a protein that in humans is encoded by the TMEM50A gene. [5] [6] [7]This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein.
19743 Ensembl ENSG00000112077 ENSMUSG00000023926 UniProt Q02094 Q9QUT0 RefSeq (mRNA) NM_000324 NM_011269 RefSeq (protein) NP_000315 NP_035399 Location (UCSC) Chr 6: 49.61 – 49.64 Mb Chr 17: 41.12 – 41.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Rh-associated glycoprotein (RHAG) is an ammonia transporter protein that in humans is encoded by the RHAG gene. RHAG has also ...