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NSAIDs cause decreased ability to form blood clots, which can increase the risk of bleeding when combined with other drugs that also decrease blood clotting, such as warfarin. [113] NSAIDs may aggravate hypertension (high blood pressure) and thereby antagonize the effect of antihypertensives, [113] such as ACE inhibitors. [114]
A Canadian study of pregnant women suggests that those taking any type or amount of NSAIDs (including ibuprofen, diclofenac, and naproxen) were 2.4 times more likely to miscarry than those not taking the medications. [51] However, an Israeli study found no increased risk of miscarriage in the group of mothers using NSAIDs. [52]
Nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate pain by counteracting the cyclooxygenase (COX) enzyme. [1] On its own, COX enzyme synthesizes prostaglandins, creating inflammation. In whole, the NSAIDs prevent the prostaglandins from ever being synthesized, reducing or eliminating the inflammation and resulting pain. [citation needed]
Over time, high blood pressure can cause damage to the arteries that can lead to health conditions including stroke, heart disease, kidney problems and dementia. There are multiple risk factors ...
Arthritis can be uncomfortable, but you don't have to just suffer through it. Try these doctor-recommended arthritis pain relief options.
The importance of developing such drugs was increased when COX-2-specific NSAIDs rofecoxib (Vioxx) and lumiracoxib (Prexige) were removed from major pharmaceutical markets in the mid-2000s due to vascular safety concerns. In addition, traditional NSAIDs increase blood pressure and interfere with the actions of antihypertensive drugs.
Certain underlying health conditions can increase the risk of gout as well: Kidney disease. Obesity. Diabetes. High blood pressure. Heart disease. Taking certain types of medications can ...
Aspirin and other NSAIDs can cause abnormally high blood levels of potassium by inducing a hyporeninemic hypoaldosteronism state via inhibition of prostaglandin synthesis; however, these agents do not typically cause hyperkalemia by themselves in the setting of normal renal function and euvolemic state. [220]