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Zoliflodacin (development codes AZD0914 and ETX0914) is an experimental antibiotic that is being studied for the treatment of infection with Neisseria gonorrhoeae (). [1] It has a novel mechanism of action which involves inhibition of bacterial type II topoisomerases. [2]
The antibiotic, which would be the first new gonorrhea treatment approved in decades, could make it to market by 2025. The World Health Organization estimates that globally there are more than 82 ...
Each drug should be administered as a single dose, with the gentamicin entering intramuscularly at a concentration of 240 mg, along with 2 g of azithromycin taken orally. [79] If an individual is not allergic to cephalosporins but ceftriaxone is unavailable, an alternative treatment is a single dose of 800 mg cefixime consumed orally. [79]
Gonorrhoea or gonorrhea, colloquially known as the clap, [7] is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae. [8] Infection may involve the genitals, mouth, or rectum. [9] Gonorrhea is spread through sexual contact with an infected person, [1] or from a mother to a child during birth. [1]
The WHO's program for monitoring trends in drug-resistant gonorrhea found in a study that from 2009 to 2014 there was widespread resistance to the first-line medicine ciprofloxacin, increasing ...
A study out of the University of York shows that carbon monoxide-releasing molecules could be the key to developing a new antibiotic to treat gonorrhea.
Neisseria gonorrhoeae, the bacterium that causes the sexually transmitted infection gonorrhea, has developed antibiotic resistance to many antibiotics. The bacteria was first identified in 1879. [1] In the 1940s effective treatment with penicillin became available, but by the 1970s resistant strains predominated. Resistance to penicillin has ...
Adalja says that everyone should be concerned about acquiring drug-resistant forms of gonorrhea because it is more difficult and complicated to treat. He adds: “It is likely that rates of ...