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Hydrogels can be used as drug delivery vehicles, for transdermal application, ophthalmic drug delivery, [11] cancer treatment [12] or for wound dressing. [ 7 ] [ 13 ] As a type of water based formulation, hydrogels are generally less greasy and are easier to be removed than oil-based formulations like organogels. [ 6 ]
A hydrogel is a biphasic material, a mixture of porous and permeable solids and at least 10% of water or other interstitial fluid. [ 1 ] [ 2 ] The solid phase is a water insoluble three dimensional network of polymers , having absorbed a large amount of water or biological fluids.
Hydrogel dressings should promote an appropriate microenvironment for angiogenesis, recruitment of fibroblasts, and cellular proliferation. [2] [4] Hydrogels respond elastically to applied stress; gels made from materials like collagen exhibit high toughness and low sliding friction, reducing damage from mechanical stress.
A few examples of hydrogel use include organ regeneration, [2] wound healing, [3] [4] [5] and drug delivery. [6] [7] Hydrogels are generally classified based on the following characteristics: material, crosslinking mechanism, physical structure, electric charge, and response to stimuli. [8]
Hollow MNs and hydrogel MNs could be used to diagnose and monitor several diseases including Cataracts, Diabetes, Cancer, and Alzheimer’s disease. [12] [29] For instance, hollow glass MNs and hydrogel MNs could extract skin interstitial fluid for the detection of glucose levels. [12] [29]
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [2]
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A nanogel is a polymer-based, crosslinked hydrogel particle on the sub-micron scale. [1] [2] [3] These complex networks of polymers present a unique opportunity in the field of drug delivery at the intersection of nanoparticles and hydrogel synthesis.
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