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  2. Diagnosis of HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/Diagnosis_of_HIV/AIDS

    Antibody tests may give false negative (no antibodies were detected despite the presence of HIV) results during the window period, hence an interval of three weeks to six months between the time of HIV exposure and the production of measurable antibodies to HIV seroconversion is implemented. Most people develop detectable antibodies ...

  3. Timeline of HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/Timeline_of_HIV/AIDS

    This is a timeline of HIV/AIDS, including but not limited to cases before 1980. Pre-1980s See also: Timeline of early HIV/AIDS cases Researchers estimate that some time in the early 20th century, a form of Simian immunodeficiency virus found in chimpanzees (SIVcpz) first entered humans in Central Africa and began circulating in Léopoldville (modern-day Kinshasa) by the 1920s. This gave rise ...

  4. Broadly neutralizing HIV-1 antibodies - Wikipedia

    en.wikipedia.org/wiki/Broadly_neutralizing_HIV-1...

    Since 2009, researchers have identified more than 50 HIV bNAbs. [6] In 2006, a Malawian man joined a study within weeks of becoming infected. Over a year, he repeatedly donated blood, which researchers used to create a timeline of changes in his virus' gp120, his antibody response and the ultimate emergence of a bNAb.

  5. HIV vaccine development - Wikipedia

    en.wikipedia.org/wiki/HIV_vaccine_development

    These antibodies mimic CD4 and compete for the conserved CD4 binding site. These antibodies all share a germline origin in the V H chain, where only a few human alleles of the IVIG1-2 gene are able to produce such an antibody. [8] Env is a protein on the HIV surface that enables to infect cells. Env extends from the surface of the HIV virus ...

  6. p24 capsid protein - Wikipedia

    en.wikipedia.org/wiki/P24_capsid_protein

    P24 is a target for the immune system, and antibodies against p24 are used in diagnostic tests to detect the presence of HIV antibodies. Fourth-generation HIV immunoassays detect viral p24 protein in the blood and patient antibodies against the virus. Previous generation tests relied on detecting patient antibodies alone; it takes about 3–4 ...

  7. Seroconversion - Wikipedia

    en.wikipedia.org/wiki/Seroconversion

    The immune system may take several days or weeks to detect antigen in tissue, begin to create antibodies, and ramp up the production of antibodies to counter the antigen. As a result, the antigen molecules outnumber the antibody molecules in the early stages of an infection.

  8. HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/HIV/AIDS

    The acute viremia is almost invariably associated with activation of CD8 + T cells, which kill HIV-infected cells, and subsequently with antibody production, or seroconversion. The CD8 + T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4 + T cell counts recover.

  9. Pathophysiology of HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/Pathophysiology_of_HIV/AIDS

    This acute viremia is associated in virtually all people with the activation of CD8 + T cells, which kill HIV-infected cells, and subsequently with antibody production, or seroconversion. The CD8 + T cell response is thought to be important in controlling virus levels, which peak and then decline, as the CD4 + T cell counts rebound.

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