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Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10 000 mU/mL) include any anemia, and hypoxemia due to chronic lung disease and mouth disease. Erythropoietin is produced by interstitial fibroblasts in the kidney in close association with the peritubular capillary and proximal convoluted tubule.
Erythropoietin is also used to treat anemia in people, and cats and dogs, with chronic kidney disease who are not on dialysis (those in Stage 3 or 4 disease and those living with a kidney transplant). There are two types of erythropoietin for people, and cats and dogs, with anemia due to chronic kidney disease (not on dialysis). [12] [13]
Recombinant erythropoietin (EPO) is very effective in treating the diminished red blood cell production that accompanies end-stage kidney disease. Erythropoietin is a sialoglycoprotein hormone produced by peritubular cells of kidney.
"Testosterone stimulates the production of a hormone called erythropoietin (EPO) and decreases the production of a hormone called hepcidin," Staheli says. ... Kidney and liver disease. Obesity ...
Erythropoiesis-stimulating drugs, [3] erythropoietin-type blood factors [2] Use: Anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS [1] [2] ATC code: B03XA: Legal status; In Wikidata
A feedback loop involving erythropoietin helps regulate the process of erythropoiesis so that, in non-disease states, the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to sustain adequate tissue oxygen levels but not so high as to cause sludging, thrombosis, or stroke ...
Kidney failure, also known as renal failure or end-stage renal disease (ESRD), ... As the kidneys fail, they produce less erythropoietin, resulting in decreased ...
The Phase 3 clinical trials were conducted in chronic kidney disease patients which were not on dialysis [6] as well as on dialysis. [7] Desidustat is developed for the treatment of anemia as an oral tablet, where currently injections of erythropoietin and its analogues are drugs of choice.
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