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Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas. [1]
The distinctive solid black colour of the Ayam Cemani (rooster shown) chicken breed is due to hyperpigmentation, with the bird's feathers, skin, beak and internal organs all being affected. Hyperpigmentation can be caused by sun damage, inflammation , or other skin injuries, including those related to acne vulgaris .
Any condition that causes the eyes to itch can contribute to darker circles due to rubbing or scratching the skin around them. Hay fever sufferers in particular will notice under-eye "smudges" during the height of the allergy season. Atopy can lead to frequent rubbing of the eyes, leading to local inflammation and increased pigmentation. [4]
Conditions of the mucous membranes involve the moist linings of the eyes, nose, mouth, genitals, and anus. [34] Acatalasia (acatalasemia, Takahara's disease) Acquired dyskeratotic leukoplakia; Actinic cheilitis (actinic cheilosis)
An allergic shiner is a dark discoloration below the eye that is associated with allergic rhinitis and is often seen in conjunction with bilateral Dennie–Morgan folds. These shiners are caused by venous congestion within the infraorbital groove , particularly from the nose .
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What causes myasthenia gravis? Because MG is an autoimmune disorder , it's caused by dysfunction within the immune system − though the source of the dysfunction is not entirely known or understood.
The diagnosis of POHS is based on the clinical triad of multiple white, atrophic choroidal scars, peripapillary pigment changes (dark spots around optic disc of the eye), and a maculopathy caused by choroidal neovascularization. Completely distinct from POHS, acute ocular histoplasmosis may rarely occur in immunodeficiency. [1] [2]