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Starting in the 2010s, some journals began questioning whether significance testing, and particularly using a threshold of α =5%, was being relied on too heavily as the primary measure of validity of a hypothesis. [52] Some journals encouraged authors to do more detailed analysis than just a statistical significance test.
Generalized linear models are used to perform the tests for statistical significance and as the number of genes is high, multiple tests correction have to be considered. [34] Some examples of other analysis on genomics data comes from microarray or proteomics experiments. [35] [36] Often concerning diseases or disease stages. [37]
In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
Although antibiotic sensitivity testing is done in a laboratory , the information provided about this is often clinically relevant to the antibiotics in a person . [36] Sometimes, a decision must be made for some bacteria as to whether they are the cause of an infection, or simply commensal bacteria or contaminants, [ 28 ] such as ...
The table shown on the right can be used in a two-sample t-test to estimate the sample sizes of an experimental group and a control group that are of equal size, that is, the total number of individuals in the trial is twice that of the number given, and the desired significance level is 0.05. [4] The parameters used are:
In medicine and medical statistics, the gold standard, criterion standard, [1] or reference standard [2] is the diagnostic test or benchmark that is the best available under reasonable conditions. [3] It is the test against which new tests are compared to gauge their validity, and it is used to evaluate the efficacy of treatments. [1]
These grades are assigned based on agreed upon values called breakpoints. Breakpoints are published by standards development organizations such as the U.S. Clinical and Laboratory Standards Institute (CLSI), the British Society for Antimicrobial Chemotherapy (BSAC) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST).
An assay (analysis) is never an isolated process, as it must be accompanied with pre- and post-analytic procedures. Both the communication order (the request to perform an assay plus related information) and the handling of the specimen itself (the collecting, documenting, transporting, and processing done before beginning the assay) are pre-analytic steps.