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People with TIC most often present with symptoms of congestive heart failure and/or symptoms related to their irregular heart rhythm. [1] Symptoms of congestive heart failure can include shortness of breath, ankle swelling, fatigue, and weight gain. [2] Symptoms of an irregular heart rhythm can include palpitations and chest discomfort. [2]
Persons with congestive heart failure may be considered for surgical insertion of an ICD or a pacemaker which can improve heart function. In cases where the heart failure is irreversible and worsening, heart transplant may be considered. [7]
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood. Although symptoms vary based on which side of the heart is affected, HF typically presents with shortness of breath , excessive fatigue , and bilateral leg swelling . [ 3 ]
Heart failure has historically been irreversible, but a new study suggests that could change. At the University of Utah, scientists used a new gene therapy that reversed heart failure in animals.
Cardiac contractility modulation therefore restores the structure and function of damaged cells back towards their normal state. In some cases, disease-related changes in the ventricular heart structure can be partially reversed by cardiac contractility modulation through a process known as reverse remodeling of the heart. [3] [4] [5] [18] [40 ...
The heart is located on the right side of the thorax, the stomach and spleen on the right side of the abdomen and the liver and gall bladder on the left side. The heart's normal right atrium occurs on the left, and the left atrium is on the right. The lung anatomy is reversed and the left lung has three lobes while the right lung has two lobes.
Over time, however, as the heart undergoes ongoing remodeling, it becomes less elliptical and more spherical. Ventricular mass and volume increase, which together adversely affect cardiac function. Eventually, diastolic function, or the heart's ability to relax between contractions may become impaired, further causing decline. [7]
Typically, these constrictions are fully reversed by rapidly acting nitroglycerin. [4] [16] Individuals with variant angina may have many undocumented episodes of symptom-free coronary artery spasm that are associated with poor blood flow to portions of the heart and subsequent irregular and potentially serious heart arrhythmias.
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