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HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4. [7] Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer. [8]
Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [ 5 ] [ 6 ] [ 7 ] Hox-C6 expression is highest in the fallopian tube and ovary. [ 8 ] HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.
Six Hox genes are dispersed in the genome of Caenorhabditis elegans, a roundworm. [10]: fig. 3 Hydra and Nematostella vectensis, both in the phylum Cnidaria, have a few Hox/ParaHox-like homeobox genes. [55] [11] Hox gene expression has also been studied in brachiopods, [56] annelids, [57] and a suite of molluscs. [58]
The HOX gene contains four clusters (A, B, C, and D). The sense strand of the HOXA gene codes for proteins. Alternative names for HOXA11-AS lncRNA are: HOXA-AS5, HOXA11S, HOXA11-AS1, HOXA11AS, or NCRNA00076. This gene is 3,885 nucleotides long and resides at chromosome 7 (7p15.2) and is transcribed from an independent gene promoter.
[18] [19] The regulation of Hox genes is highly complex and involves reciprocal interactions, mostly inhibitory. Drosophila is known to use the polycomb and trithorax complexes to maintain the expression of Hox genes after the down-regulation of the pair-rule and gap genes that occurs during larval development.
15426 Ensembl ENSG00000037965 n/a UniProt P31273 P09025 RefSeq (mRNA) NM_022658 NM_010466 RefSeq (protein) NP_073149 NP_034596 Location (UCSC) Chr 12: 54.01 – 54.01 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene. Function This gene belongs to the homeobox family of genes. The homeobox genes encode ...
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15424 Ensembl ENSG00000172789 ENSMUSG00000022485 UniProt Q00444 P32043 RefSeq (mRNA) NM_018953 NM_175730 RefSeq (protein) NP_061826 NP_783857 Location (UCSC) Chr 12: 54.03 – 54.04 Mb Chr 15: 102.88 – 102.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene. Function This gene belongs to the homeobox ...