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Drugs affected by grapefruit juice; Drug class Major Interactions Minor interactions Antiarrhythmic agents: amiodarone (Cordarone) dronedarone dofetilide (Tikosyn) Antihistamines: terfenadine (Seldane) (off the market) diphenhydramine (partially) astemizole (off the market) Calcium channel antagonists: felodipine (Plendil)
Cimetidine: Cimetidine inhibits CYP450 enzymes involved in metabolism of CCBs. Blood concentration of calcium channel antagonists increase leading to higher incidence of side effects (hot flushes). Grape fruit juice: Grapefruit juice suppresses enzymes metabolizing calcium channel antagonists (cytochrome P450) and reduces the clearance.
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. ... "Many food-drug interactions and potential side effects can be avoided by following ...
Homodynamic effects include drugs that act as (1) pure agonists, if they bind to the main locus of the receptor, causing a similar effect to that of the main drug, (2) partial agonists if, on binding to a secondary site, they have the same effect as the main drug, but with a lower intensity and (3) antagonists, if they bind directly to the ...
Common side effects include constipation, ... A lower dose is also recommended in people taking the calcium channel blockers, ... (946 ml) of grapefruit juice per day.
Antihypertensive agents are classified according to their mechanism of actions. The most common classes prescribed are diuretics, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) and beta-blockers. Antihyperlipidemic agents most often prescribed are statins, ezetimibe and ...
Lercanidipine (trade name Zanidip, among others) is an antihypertensive (blood pressure lowering) drug. It belongs to the dihydropyridine class of calcium channel blockers, which work by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
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