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This includes studies on supplements containing glucosamine, chondroitin sulfate, and methylsulfonylmethane (MSM). [20] Because they are not regulated, joint supplements are not required to contain what has been listed on the label. [7] Additionally, oral joint supplements may have questionable bioavailability. [21]
[4] [6] Glucosamine is marketed as a supplement to support the structure and function of joints, and the marketing is targeted to people with osteoarthritis. [4] [6] Commonly sold forms of glucosamine are glucosamine sulfate, [4] glucosamine chondroitin, glucosamine hydrochloride, [5] and N-acetylglucosamine.
Normally, joint cartilages have proteoglycan complexes, which are proteins with side chains made of glycosaminoglycans such as keratan sulfate and chondroitin sulfate attached to strands of hyaluronic acid. The glycosaminoglycan side chains are polyanionic, which causes adjacent side chains to push each other away and create a "bottle brush ...
The Long-term Evaluation of Glucosamine Sulfate (LEGS) study ran between 2007 and 2011, [61] to study whether glucosamine sulfate, chondroitin sulfate or a combination of both are effective treatments for chronic knee pain due to osteoarthritis. 502 patients (from 605 enrolled) were followed for two years. [62]
"Chondroitin sulfate B" is an old name for dermatan sulfate, and it is no longer classified as a form of chondroitin sulfate. [25] Chondroitin, without the "sulfate", has been used to describe a fraction with little or no sulfation. [26] However, this distinction is not used by all.
Additionally, horses with a hind limb lameness will tend to reduce the degree of leg use. To do so, some horses will reduce the contraction time of the gluteals on the side of the lame leg, leading to a "hip roll" or "hip dip" and appearance that the hip drops a greater degree on the side of the lame leg. [10]
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