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Rapamycin is a drug primarily used to prevent organ transplant rejection. Kaeberlein said it can increase the life of a mouse by 30 percent – though scientists aren't sure why. "It's a three ...
The Dog Aging Project is an open science initiative. The investigators have committed to releasing all anonymized research data to the public domain. The longitudinal study portion of the Dog Aging Project bears some similarity to the Golden Retriever Lifetime Study of the Morris Animal Foundation although with much larger phenotypic diversity.
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
For the anti-aging effect, most people dose weekly from between three and ten mg. We decided on a dose of 4 mg once weekly for me. There is no known toxic dose for sirolimus so I felt good about that.
A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals. [1] [2] Some possible geroprotectors include melatonin, [3] carnosine, [4] metformin, [5] rapamycin, [6] nicotinamide mononucleotide (NMN) [7] and delta sleep-inducing peptide.
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