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Technetium-99 (99 Tc) is an isotope of technetium which decays with a half-life of 211,000 years to stable ruthenium-99, emitting beta particles, but no gamma rays. It is the most significant long-lived fission product of uranium fission, producing the largest fraction of the total long-lived radiation emissions of nuclear waste .
Technetium-99m (99m Tc) is a metastable nuclear isomer of technetium-99 (itself an isotope of technetium), symbolized as 99m Tc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world.
A nuclear pharmacist adds anywhere from 50 - 100 mCi of Na[99m TcO 4] to the reaction vial to make the final product, in the pH range of 3.8 to 8.0. After being allowed to react at room temperature for 15 minutes to ensure maximum labeling of the human albumin with 99m Tc, the kit can then be diluted with sterile normal saline as needed.
Many radiopharmaceuticals use technetium-99m (Tc-99m) which has many useful properties as a gamma-emitting tracer nuclide. In the book Technetium a total of 31 different radiopharmaceuticals based on Tc-99m are listed for imaging and functional studies of the brain, myocardium, thyroid, lungs, liver, gallbladder, kidneys, skeleton, blood and ...
A Tc-99m pertechnetate solution is being eluted from Mo-99 molybdate bound to a chromatographic substrate. A technetium-99m generator, or colloquially a technetium cow or moly cow, is a device used to extract the metastable isotope 99m Tc of technetium from a decaying sample of molybdenum-99.
97m Tc is the most stable, with a half-life of 91.0 days (0.097 MeV). [4] This is followed by 95m Tc (half-life: 61 days, 0.038 MeV) and 99m Tc (half-life: 6.04 hours, 0.143 MeV). 99m Tc only emits gamma rays, subsequently decaying to 99 Tc. [7] For isotopes lighter than 98 Tc, the primary decay mode is electron capture to isotopes of molybdenum.
Technetium (99m Tc) pentetic acid, sold under the brand name Draximage DTPA among others, is a radiopharmaceutical medication used in nuclear medicine to image the brain, kidneys, or lungs. [1] It is given by intravenous injection or via aerosol spray. [ 1 ]
99m Tc-MDP must be prepared in a radiopharmacy.It is usually supplied as a "cold kit" to which radioactive 99m Tc from a generator is added. Kit composition may vary between suppliers, but contents typically includes medronic acid, stannous chloride dihydrate and sometimes ascorbic acid. [4]