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A protein is predicted to be "druggable" if it is a member of a protein family [4] for which other members of the family are known to be targeted by drugs (i.e., "guilt" by association). While this is a useful approximation of druggability, this definition has limitations for two main reasons: (1) it highlights only historically successful ...
The Human Protein Atlas contains information about the human proteins in cells, tissues, and organs. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome.
Proteogenomics uses an integrated approach by combining genomics, proteomics, and transcriptomics.. Proteogenomics is a field of biological research that utilizes a combination of proteomics, genomics, and transcriptomics to aid in the discovery and identification of peptides.
The Human Proteome Project [1] (HPP) is a collaborative effort coordinated by the Human Proteome Organization. [2] Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome .
This prize is awarded to a member for distinguished contributions to the field of biochemistry and molecular biology. The University of New South Wales awarded Wilkins a Doctor of Science (D. Sc.) in 2018. Recently, he has enjoyed collaborating on the Human Proteome Project (published 2020) and the Human RNA Atlas Project (published 2021).
Human Proteinpedia, which is closely associated with Institute of Bioinformatics (IOB), Bangalore and Johns Hopkins University, is a portal for sharing and integration of human proteomic data. [ 1 ] [ 2 ] It allows research laboratories to contribute and maintain protein annotations.
The human leukocyte antigen (HLA) system, also referred to as the major histocompatibility complex (MHC), is a complex of genes important for the adaptive immune system. Mutations in the HLA complex have been associated with an increased risk of developing hypersensitivity reactions in response to certain medications.
The G-value paradox arises from the lack of correlation between the number of protein-coding genes among eukaryotes and their relative biological complexity. The microscopic nematode Caenorhabditis elegans, for example, is composed of only a thousand cells but has about the same number of genes as a human.