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[51] [52] Marine fishes and vertebrate thyroid glands have the highest concentration of selenium and iodine. From about 500 Mya, freshwater and terrestrial plants slowly optimized the production of "new" endogenous antioxidants such as ascorbic acid (Vitamin C), polyphenols (including flavonoids), tocopherols , etc.
Selenium is a cofactor for the three thyroid hormone deiodinases, helping activate and then deactivate various thyroid hormones and their metabolites. Isolated selenium deficiency is now being investigated for its role in the induction of autoimmune reactions in the thyroid gland in Hashimoto's disease . [ 162 ]
T 3, through binding a nuclear thyroid hormone receptor, influences the expression of genes in practically every vertebrate cell. [2] [3] Iodothyronine deiodinases are unusual in that these enzymes contain selenium, in the form of an otherwise rare amino acid selenocysteine. [4] [5] [6]
They contain double the recommended daily dose of selenium, a mineral that improves thyroid function and fights inflammation. Selenium intake is often not a high priority for many people, so have ...
Selenium plays a critical role in DNA synthesis, thyroid hormone health, reproduction, and protecting the body from oxidative stress and damage. Just three ounces of catfish has 22% of the daily ...
Selenium in iodothyronine deiodinase, as selenocysteine, plays a crucial role in determining the free circulating levels of T 3. Selenium deficiency can have implications in fall of T 3 levels. References
Selenium is also necessary for the conversion of the thyroid hormone thyroxine (T4) into its more active counterpart triiodothyronine (T3), [3] and as such a deficiency can cause symptoms of hypothyroidism, including extreme fatigue, mental slowing, goiter, cretinism, and recurrent miscarriage. [5]
It's also packed with important nutrients such as vitamin D, selenium and iodine, which support immune function, bone health and thyroid regulation.
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