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Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-β, IGF) signalling. Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. [1]
The following bones develop in humans via Intramembranous ossification: [3] Flat bones of the face; Most of the bones of the skull; Clavicles; Other bone that formed by intramembranous ossification are: cortices of tubular and flat bones as well as the calvaria, upper facial bones, tympanic temporal bone, vomer, and medial pterygoid process. [4]
The flat bones are: the occipital, parietal, frontal, nasal, lacrimal, vomer, sternum, ribs, and scapulae. [1] These bones are composed of two thin layers of compact bone enclosing between them a variable quantity of cancellous bone, [1] which is the location of red bone marrow. In an adult, most red blood cells are formed in flat
Endochondral ossification is responsible for development of most bones including long and short bones, [4] the bones of the axial (ribs and vertebrae) and the appendicular skeleton (e.g. upper and lower limbs), [5] the bones of the skull base (including the ethmoid and sphenoid bones) [6] and the medial end of the clavicle. [7]
The bones that form the base and facial regions of the skull develop through the process of endochondral ossification. In this process, mesenchyme accumulates and differentiates into hyaline cartilage, which forms a model of the future bone. The hyaline cartilage model is then gradually, over a period of many years, displaced by bone.
The occipital bone overlies the occipital lobes of the cerebrum. At the base of the skull in the occipital bone, there is a large oval opening called the foramen magnum, which allows the passage of the spinal cord. Like the other cranial bones, it is classed as a flat bone. Due to its many attachments and features, the occipital bone is ...
Skull in situ Human head skull from side Anatomy of a flat bone – the periosteum of the neurocranium is known as the pericranium Human skull from the front Side bones of skull. The human skull is the bone structure that forms the head in the human skeleton. It supports the structures of the face and forms a cavity for the brain. Like the ...
Flat bones are thin and generally curved, with two parallel layers of compact bone sandwiching a layer of spongy bone. Most of the bones of the skull are flat bones, as is the sternum. [39] Sesamoid bones are bones embedded in tendons. Since they act to hold the tendon further away from the joint, the angle of the tendon is increased and thus ...