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The fungal protein ERG2, a C-8 sterol isomerase, falls into the same protein family as sigma-1. Both localize to the ER membrane, although sigma-1 is also reported to be a cell surface receptor. Sigma-2 is an EXPERA domain protein [4] with a mostly intracellular (ER membrane) localization. [5]
The σ 1 receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). [13]
27346 69071 Ensembl ENSG00000109084 ENSMUSG00000037278 UniProt Q5BJF2 Q8VD00 RefSeq (mRNA) NM_014573 NM_133706 RefSeq (protein) NP_055388 NP_598467 Location (UCSC) Chr 17: 28.32 – 28.33 Mb Chr 11: 78.43 – 78.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The sigma-2 receptor (σ 2 R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases ...
When mice are in a steady state, IL-17 produced by the γδ17 T cells will stimulate stromal cells expressing the IL-17 receptor to produce IL-33 in vivo, and therefore provide a molecular link to T reg cells expressing the IL-33 receptor ST2 in the adipose tissue, so ST2+ Treg cells will accumulate and this will lead to the maintenance of ...
During ADCC, FcγRIII receptors on the surface of natural killer (NK) cells stimulate the NK cells to release cytotoxic molecules from their granules to kill antibody-covered target cells. [25] FcεRI has a different function. FcεRI is the Fc receptor on granulocytes, that is involved in allergic reactions and defense against parasitic infections.
Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties. A non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood vessel growth through reduction of free VEGF and PlGF concentrations. [1]
It acts through at least two types of receptors termed AT 1 and AT 2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin–angiotensin system. This receptor mediates programmed cell death .
The immunoglobulin light chain genes in tetrapods can be classified into three distinct groups: kappa (κ), lambda (λ), and sigma (σ). The divergence of the κ, λ, and σ isotypes preceded the radiation of tetrapods. The σ isotype was lost after the evolution of the amphibian lineage and before the emergence of the reptilian lineage.