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The submucosa (or tela submucosa) is a thin layer of tissue in various organs of the gastrointestinal, respiratory, and genitourinary tracts. It is the layer of dense irregular connective tissue that supports the mucosa ( mucous membrane ) and joins it to the muscular layer , the bulk of overlying smooth muscle (fibers running circularly within ...
Although this is a congenital lesion, airway sounds typically begin at age 4–6 weeks. Until that age, inspiratory flow rates may not be high enough to generate the sounds. Symptoms typically peak at age 6–8 months and remit by age 2 years. Late-onset laryngomalacia may be a distinct entity, which can present after age of 2 years.
The submucosa is the tissue that connects the mucosa to the muscle outside the tube. The glands themselves are quite complex. The mucus factory is at the bottom, in the submucosa, it is composed of many little sacs (acini) where the mucus originates. Each sac (acinus) has one end that can open and close (dilate) to allow the mucus out.
Deeper invasion into the submucosa will increase the exposure to lymphatics. [8] Long-standing inflammation is a risk factor for the development of cancer. The lamina propria macrophages when under much stress release pro-inflammatory signals that may lead to increased probability of developing cancer.
Infant respiratory distress syndrome (IRDS) is the leading cause of death in premature infants. [38] Despite only 1% of all birth complications being attributed to respiratory distress syndrome, there is a significantly higher prevalence in prematurely born babies. [39]
The mucosa-associated lymphoid tissue (MALT), also called mucosa-associated lymphatic tissue, is a diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of the body, such as the gastrointestinal tract, nasopharynx, thyroid, breast, lung, salivary glands, eye, and skin.
The submucosa consists of a dense and irregular layer of connective tissue with blood vessels, lymphatics, and nerves branching into the mucosa and muscular layer. It contains the submucous plexus , and enteric nervous plexus , situated on the inner surface of the muscular layer.
Around 800 to 1,000 minor salivary glands are located throughout the oral cavity within the submucosa [12] of the oral mucosa in the tissue of the buccal, labial, and lingual mucosa, the soft palate, the lateral parts of the hard palate, and the floor of the mouth or between muscle fibers of the tongue. [13]