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Granulosa cell tumours are tumours that arise from granulosa cells.They are estrogen-secreting tumours and present as large, complex, ovarian masses. These tumours are part of the sex cord–gonadal stromal tumour or non-epithelial group of tumours.
In contrast, the epithelial cells originate from the outer epithelial lining surrounding the gonad while the germ cell tumors arise from the precursor cells of the gametes, hence the name germ cell. [1] In humans, this group accounts for 8% of ovarian cancers and under 5% of testicular cancers. Their diagnosis is histological: only a biopsy of ...
In medicine, Meigs's syndrome, also Meigs syndrome or Demons–Meigs syndrome, is the triad of ascites, pleural effusion, and benign ovarian tumor (ovarian fibroma, fibrothecoma, Brenner tumour, and occasionally granulosa cell tumour). [1] [2] [3] Meigs syndrome resolves after the resection of the tumor. Because the transdiaphragmatic lymphatic ...
Adult granulosa cell tumors are characterized by later onset (30+ years, 50 on average). These tumors produce high levels of estrogen, which causes its characteristic symptoms: menometrorrhagia; endometrial hyperplasia; tender, enlarged breasts; postmenopausal bleeding; and secondary amenorrhea.
Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. It is also known as Abrikossoff's tumor , [ 1 ] granular cell myoblastoma , [ 1 ] granular cell nerve sheath tumor , [ 1 ] and granular cell schwannoma . [ 1 ]
The granulosa cells are usually arranged haphazardly around the space. They are pathognomonic for granulosa cell tumors. Histologically, these tumors consists of monotonous islands of granulosa cells with "coffee-bean" nuclei. That same nuclear groove appearance noted in Brenner tumour, an epithelial-stromal ovarian tumor distinguishable by ...
Cell culture of granulosa cells can be performed in vitro. Plating density (number of cells per volume of culture medium) plays a critical role for the differentiation. A lower plating density makes granulosa cells exhibit estrogen production, while a higher plating density makes them appear as progesterone producing theca lutein cells. [12]
Histologically, there are nests of transitional epithelial cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma. The coffee bean nuclei are the nuclear grooves exceptionally pathognomonic to the sex cord stromal tumour, the ovarian granulosa cell tumour, with the fluid-filled spaces Call–Exner bodies ...
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