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Myostatin inhibitors are a class of drugs that work by blocking the effect of myostatin, which inhibits muscle growth. In animal models and limited human studies, myostatin inhibitors have increased muscle size. They are being developed to treat obesity, sarcopenia, muscular dystrophy, and other illnesses.
There are currently no approved medications for the treatment of sarcopenia. [41] Testosterone or other anabolic steroids have also been investigated for treatment of sarcopenia, and seem to have some positive effects on muscle strength and mass, but cause several side effects and raise concerns of prostate cancer in men and virilization in women.
Society on Sarcopenia, Cachexia and Wasting Disorders (SCWD) is an international and multidisciplinary non-profit organization, created in 2008 that focuses on cachexia [1] and sarcopenia. [2] As they are often under-diagnosed, patient groups aim to improve their awareness. [ 3 ]
An increased subset of adults over the age of 65 have been classified as having sarcopenic obesity. There is an association between the loss in muscle mass/strength/physical function of sarcopenia and high body fat in obesity as the increased inactivity (sedentary lifestyle) that can occur with a loss in physical function and aging can lead to ...
Sarcopenia is the degenerative loss of skeletal muscle mass, quality, and strength associated with aging. [19] The rate of muscle loss is dependent on exercise level, co-existing health conditions, nutrition and other factors. Sarcopenia can lead to reduction in functional status and cause significant disability from increased muscle weakness.
Elderly people require specific attention to medications. Elderly people particularly are subjected to polypharmacy (taking multiple medications) given their accumulation of multiple chronic diseases. Many of these individuals have also self-prescribed herbal medications and over-the-counter drugs.
Sarcopenia is the degenerative loss of skeletal muscle mass, quality, and strength associated with aging. This involves muscle atrophy, reduction in number of muscle fibers and a shift towards "slow twitch" or type I skeletal muscle fibers over "fast twitch" or type II fibers. [3]
As of 2020, there are no drugs approved to treat muscle wasting in people with chronic diseases, and there is therefore an unmet need for anabolic drugs with few side effects. One aspect hindering drug approval for treatments for cachexia and sarcopenia (two types of muscle wasting) is disagreement in what outcomes would demonstrate the ...
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