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Pulmonary drug delivery is mainly utilized for topical applications in the lungs, such as the use of inhaled beta-agonists, corticosteroids and anticholinergic agents for the treatment of asthma and COPD, the use of inhaled mucolytics and antibiotics for the treatment of cystic fibrosis (CT) and respiratory viral infections, [1] and the use of inhaled prostacyclin analogs for the treatment of ...
With this device, a medical liquid (typically epinephrine chloride, used as a bronchial muscle relaxant to reverse constriction). [28] As an alternative to the expensive electrical nebulizer, many people in the 1930s continued to use the much more simple and cheap hand-driven nebulizer, known as the Parke-Davis Glaseptic. [29]
Epinephrine is also used as a bronchodilator for asthma if specific β 2 agonists are unavailable or ineffective. [39] Because of the high intrinsic efficacy (receptor binding ability) of epinephrine, high drug concentrations cause adverse side effects when treating asthma. The value of using nebulized epinephrine in acute asthma is unclear. [40]
The US Food and Drug Administration approved the first nasal spray epinephrine drug for severe allergic reactions known as anaphylaxis, providing a needle-free alternative to EpiPens and similar ...
An epinephrine autoinjector (or adrenaline autoinjector, also known by the trademark EpiPen) is a medical device for injecting a measured dose or doses of epinephrine (adrenaline) by means of autoinjector technology. It is most often used for the treatment of anaphylaxis. The first epinephrine autoinjector was brought to market in 1983.
An inhalational anesthetic is a chemical compound possessing general anesthetic properties that is delivered via inhalation. They are administered through a face mask, laryngeal mask airway or tracheal tube connected to an anesthetic vaporiser and an anesthetic delivery system.
Findings indicate that β 2 stimulants, especially in parenteral administration such as inhalation or injection, can induce adverse effects: Tachycardia secondary to peripheral vasodilation and cardiac stimulation (Such tachycardia may be accompanied by palpitations.) [4] Tremor, excessive sweating, anxiety, insomnia, and agitation [5]
At the tip of the nebulizer, the liquid is pulled into the gas stream by surface tension along a spout dipping into the gas stream. This allows the gas to impact the liquid, and has the liquid interact in the center of the gas flow where the gas flow speed is highest, producing a better transfer of energy from the gas to the liquid, and ...
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