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Forty radioisotopes have been characterized, with the most stable, besides 176 Lu, being 174 Lu with a half-life of 3.31 years, and 173 Lu with a half-life of 1.37 years. All of the remaining radioactive isotopes have half-lives that are less than 9 days, and the majority of these have half-lives that are less than half an hour.
Lutetium (177 Lu) chloride is a radioactive compound used for the radiolabeling of pharmaceutical molecules, aimed either as an anti-cancer therapy or for scintigraphy (medical imaging). [ 5 ] [ 6 ] It is an isotopomer of lutetium(III) chloride containing the radioactive isotope 177 Lu , which undergoes beta decay with a half-life of 6.64 days.
Lutetium (177 Lu) oxodotreotide or 177 Lu dotatate, brand name Lutathera, is a chelated complex of a radioisotope of the element lutetium with dotatate, used in peptide receptor radionuclide therapy. Specifically, it is used in the treatment of cancers which express somatostatin receptors. [5] It is a radiolabeled somatostatin analog. [3] [6] [7]
Lutetium usually occurs in association with the element yttrium [11] and is sometimes used in metal alloys and as a catalyst in various chemical reactions. 177 Lu-DOTA-TATE is used for radionuclide therapy (see Nuclear medicine) on neuroendocrine tumours. Lutetium has the highest Brinell hardness of any lanthanide, at 890–1300 MPa. [12]
The direct method of producing Lu-177 is by performing neutron irradiation on Lu-176 to Lu-177. This is an inexpensive and effective method to produce Lu-177. [25] In the United States, the main place that Lu-177 is produced is the University of Missouri Research Reactor. Once produced, Lu-177 is stable for 72 hours if stored below room ...
Radiation from lutetium (177 Lu) oxodotreotide can cause damage when the medicine passes through tubules in the kidney. [45] Arginine/lysine can be used to reduce renal radiation exposure during peptide receptor radionuclide therapy with lutetium ( 177 Lu) oxodotreotide.
λ is the decay constant of . t is the time since the sample is formed. The two isotopes, 176 Lu and 176 Hf, in the system are measured as ratio to the reference stable isotope of 177 Hf. [3] [4] The measured ratio can be obtained from mass spectrometry.
chemistry (mass of one atom divided by the atomic mass constant, 1 Da) Bodenstein number: Bo or Bd = / = Max Bodenstein: chemistry (residence-time distribution; similar to the axial mass transfer Peclet number) [2] Damköhler numbers: Da =
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