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Induced pluripotent stem cells are similar to natural pluripotent stem cells, such as embryonic stem cells, in many aspects, such as the expression of certain stem cell genes and proteins, chromatin methylation patterns, doubling time, embryoid body formation, teratoma formation, viable chimera formation, and potency and differentiability, but ...
Pluripotent cells: Can develop into all cell types (except those that form the amniotic sac and the placenta). For example, the early embryo consists mainly of pluripotent stem cells. Multipotent cells: Can develop into any of a family of closely related cell types. For example, blood multipotent cells can develop into various blood cells.
A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.
The term stem cell was coined by Theodor Boveri and Valentin Haecker in late 19th century. [8] Pioneering works in theory of blood stem cell were conducted in the beginning of 20th century by Artur Pappenheim, Alexander A. Maximow, Franz Ernst Christian Neumann.
Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer, and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and human cloning.
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. [ 1 ] [ 2 ] Human embryos reach the blastocyst stage 4–5 days post fertilization , at which time they consist of 50–150 cells.
A stem cell line is a group of stem cells that is cultured in vitro and can be propagated indefinitely. Stem cell lines are derived from either animal or human tissues and come from one of three sources: embryonic stem cells, adult stem cells, or induced pluripotent stem cells. They are commonly used in research and regenerative medicine.
As the induced pluripotent stem cells are passaged, the epigenetic memory of the cells diminishes and the cells gradually want to differentiate into any cell type rather than the original somatic cell type. [33] Reprogramming can also be induced artificially through the introduction of exogenous factors, usually transcription factors.