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The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
Airway basal cells are found deep in the respiratory epithelium, attached to, and lining the basement membrane. [1]Basal cells are the stem cells or progenitors of the airway epithelium and can differentiate to replenish all of the epithelial cells including the ciliated cells, and secretory goblet cells.
Club cells, also known as bronchiolar exocrine cells, [1] are low columnar/cuboidal cells with short microvilli, found in the small airways (bronchioles) of the lungs. [2] They were formerly known as Clara cells. Club cells are found in the ciliated simple epithelium. These cells may secrete glycosaminoglycans to protect
Pulmonary neuroendocrine cells (PNECs) are specialized airway epithelial cells that occur as solitary cells or as clusters called neuroepithelial bodies (NEBs) in the lung. Pulmonary neuroendocrine cells are also known as bronchial Kulchitsky cells. [2] They are located in the respiratory epithelium of the upper and lower respiratory tract.
The lungs are the largest organs in the lower respiratory tract. The lungs are suspended within the pleural cavity of the thorax. The pleurae are two thin membranes, one cell layer thick, which surround the lungs. The inner (visceral pleura) covers the lungs and the outer (parietal pleura) lines the inner surface of the chest wall. This ...
The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types in the human body". [13] By 2018, the Human Cell Atlas description based the project on the assumption that "our characterization of the hundreds of types and subtypes of cells in the ...
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There are three major types of alveolar cell. Two types are pneumocytes or pneumonocytes known as type I and type II cells found in the alveolar wall, and a large phagocytic cell known as an alveolar macrophage that moves about in the lumens of the alveoli, and in the connective tissue between them. Type I cells, also called type I pneumocytes ...