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Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export.
RNase L is an interferon-induced nuclease that, upon activation, destroys all RNA within the cell EC 3.1.26.5 : RNase P is a type of ribonuclease that is unique in that it is a ribozyme – a ribonucleic acid that acts as a catalyst in the same way as an enzyme .
ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene. ABCE1 is an ATPase that is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. [5] ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2 ...
246730 Ensembl ENSG00000089127 ENSMUSG00000052776 UniProt P00973 P11928 RefSeq (mRNA) NM_001032409 NM_002534 NM_016816 NM_001320151 NM_145211 RefSeq (protein) NP_001027581 NP_001307080 NP_002525 NP_058132 NP_660212 Location (UCSC) Chr 12: 112.91 – 112.93 Mb Chr 5: 121.03 – 121.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 2'-5'-oligoadenylate synthetase 1 is an enzyme that ...
The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'-5'-oligoadenylates, which activate latent ribonuclease (RNase-L), resulting in degradation of viral RNA and inhibition of virus replication. [1]
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Another cellular enzyme, RNAse L—also induced by interferon action—destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. Inhibited protein synthesis impairs both virus replication and infected host cells.
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related to: rnase l