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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [1] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals. [3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.
An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804. [3] [4]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U36 is encoded within the intron of ribosomal protein rpL7a, and has two regions of complementarity to 18S and 28S ribosomal RNA. This complementarity suggests that U36 acts as a 2'-O-ribose methylation guide.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [ 1 ] U32 is encoded within intron 2 of the ribosomal protein L13 gene in human and mouse [ 2 ] and is predicted to guide the 2'O-ribose methylation of both 18S ribosomal RNA (rRNA) residue G1328 and 28S rRNA residue A1511.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting. [2] SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279. [ 3 ] In the human genome this snoRNA is located in the introns of the same host gene (C6orf48) as another C/D box snoRNA U52 (also known as SNORD52).