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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [1] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804. [3] [4]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U38 is located in introns 4 and 5 of ribosomal protein S8 in human and in the homologous genes in mouse and cow. [2] U38 is predicted to guides the methylation of 2'-O-ribose residues in 28S ribosomal RNA (rRNA). The mouse ...
This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting. [2] SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279. [ 3 ] In the human genome this snoRNA is located in the introns of the same host gene (C6orf48) as another C/D box snoRNA U52 (also known as SNORD52).
Most of the members of the C/D box family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] SNORD100 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue G436.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] SNORD94 is predicted to guide the 2'O-ribose methylation of C62 of the snRNA U6 .