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Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export.
RNase L is an interferon-induced nuclease that, upon activation, destroys all RNA within the cell EC 3.1.26.5 : RNase P is a type of ribonuclease that is unique in that it is a ribozyme – a ribonucleic acid that acts as a catalyst in the same way as an enzyme .
ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene. ABCE1 is an ATPase that is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. [5] ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2 ...
246730 Ensembl ENSG00000089127 ENSMUSG00000052776 UniProt P00973 P11928 RefSeq (mRNA) NM_001032409 NM_002534 NM_016816 NM_001320151 NM_145211 RefSeq (protein) NP_001027581 NP_001307080 NP_002525 NP_058132 NP_660212 Location (UCSC) Chr 12: 112.91 – 112.93 Mb Chr 5: 121.03 – 121.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 2'-5'-oligoadenylate synthetase 1 is an enzyme that ...
The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'-5'-oligoadenylates, which activate latent ribonuclease (RNase-L), resulting in degradation of viral RNA and inhibition of virus replication. [1]
Ribonuclease L or RNase L (for latent), ais an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export. [6] [7] RNase L is an enzyme that in humans is encoded by the RNASEL gene in humans.
In comparison, RNase A, a protein that catalyzes the same reaction, uses a coordinating histidine and lysine to act as a base to attack the phosphate backbone. [ 2 ] [ clarification needed ] Like many protein enzymes, metal binding is also critical to the function of many ribozymes. [ 9 ]
RNase MRP: mitochondrial RNA processing ribonuclease RF00030: RNase P: ribonuclease P RF00010: A type of ribonuclease which cleaves RNA scaRNA: small Cajal body-specific RNA RF00553: scnRNA small-scan RNA - scRNA small cytoplasmic RNA - scRNA: small conditional RNA - SgrS RNA: sugar transport-related sRNA RF00534