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RNase L activation pathway-IFN factors bind the receptor and lead transcription and modifications of OAS.Viral dsRNA binds OAS, so that 2'-5'A is produced leading to the dimerization of RNase L. Activated RNase L cleaves all RNA in the cell, which can activate MDA5 leading to interferon production.
246730 Ensembl ENSG00000089127 ENSMUSG00000052776 UniProt P00973 P11928 RefSeq (mRNA) NM_001032409 NM_002534 NM_016816 NM_001320151 NM_145211 RefSeq (protein) NP_001027581 NP_001307080 NP_002525 NP_058132 NP_660212 Location (UCSC) Chr 12: 112.91 – 112.93 Mb Chr 5: 121.03 – 121.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 2'-5'-oligoadenylate synthetase 1 is an enzyme that ...
59 kDa 2'-5'-oligoadenylate synthetase-like protein is an enzyme that in humans is encoded by the OASL gene. [5] [6]2'-5'-oligoadenylate synthase is a protein family of structurally similar proteins, including OAS1, OAS2, and OAS3.
246727 Ensembl ENSG00000111331 ENSMUSG00000032661 UniProt Q9Y6K5 Q8VI93 RefSeq (mRNA) NM_006187 NM_145226 RefSeq (protein) NP_006178 NP_660261 Location (UCSC) Chr 12: 112.94 – 112.98 Mb Chr 5: 120.89 – 120.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene. This gene encodes an enzyme ...
In molecular biology, 2'-5'-oligoadenylate synthetase (2-5A synthetase) is an enzyme (EC 2.7.7.84) that reacts to interferon signal. It is an antiviral enzyme that counteracts viral attack by degrading RNAs, both viral and host.
Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.
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This has involved studies of the interferon antagonists that are encoded by the coronavirus, specifically phosphodiesterase, which antagonizes OAS-RNase L (Ribonuclease L) immune pathway. [10] Weiss has considered the mechanisms by which the phosphodiesterase antagonizes Ribonuclease L.