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Metformin is an FDA-approved antidiabetic agent that manages high blood sugar levels in type 2 diabetes patients. It reduces glucose absorption from the intestines, lowers liver glucose production, and improves insulin sensitivity. Metformin is recommended with dietary changes and exercise for better results.
Applies to metformin: compounding powder, oral solution, oral suspension extended release, oral tablet, oral tablet extended release. General adverse events Gastrointestinal events such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite have been frequently reported during therapy initiation and resolve spontaneously in most cases.
Maximum dose: 2550 mg/day Extended-release: Initial dose: 500 to 1000 mg orally once a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2500 mg daily Comments:-Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus.
When initiating therapy in patients currently receiving insulin, metformin should be started at 500 mg orally once a day and titrated in 500 mg increments weekly. When fasting blood glucose levels decrease to less than 120 mg/dL, consider decreasing the insulin dose by 10% to 25%.
Metformin Hydrochloride 500 mg (G 10) View larger images Drugs.com Mobile App Access drug & treatment information, identify pills, check interactions and set up personal medication records.
It is not known how metformin affects the fetus or a breastfed infant. 6. Response and effectiveness. The peak effects of metformin are seen within 2-3 hours with immediate-release forms or 4 to 8 hours with slow-release forms. May take up to 2 weeks of regular dosing for the maximum effects of metformin to develop. 7. Interactions
Patients currently receiving metformin hydrochloride: Initially, 500 mg of metformin hydrochloride and 50 mg of sitagliptin twice daily or 1 g of metformin hydrochloride and 50 mg of sitagliptin twice daily, depending on the patient's existing dosage of metformin hydrochloride.
Metformin hydrochloride tablets, USP contain 500 mg, 850 mg or 1,000 mg of metformin hydrochloride, which is equivalent to 389.93 mg, 662.88 mg, 779.86 mg metformin base, respectively. Each tablet contains the inactive ingredients povidone and magnesium stearate.
Dosage forms: oral tablet (1000 mg-50 mg; 500 mg-50 mg), oral tablet, extended release (1000 mg-100 mg; 1000 mg-50 mg; 500 mg-50 mg) Drug class: Antidiabetic combinations. Medically reviewed by Drugs.com on Feb 26, 2024. Written by Cerner Multum. Uses; Side effects; Warnings; Before taking; Dosage; Interactions
Patients with Inadequate Glycemic Control on Glipizide (or another Sulfonylurea) and /or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: