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  2. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    Metformin has an oral bioavailability of 50–60% under fasting conditions, and is absorbed slowly. [9] [131] Peak plasma concentrations (C max) are reached within 1–3 hours of taking immediate-release metformin and 4–8 hours with extended-release formulations.

  3. Is There a Best Time to Take Metformin? - AOL

    www.aol.com/best-time-metformin-165700094.html

    People with type 2 diabetes take metformin to help control high blood sugar levels. Diabetes can cause many health issues, including sexual health challenges like erectile dysfunction (ED).

  4. 6 Benefits of Taking Metformin (Besides Weight Loss) - AOL

    www.aol.com/6-benefits-taking-metformin-besides...

    2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.

  5. Cmax (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Cmax_(pharmacology)

    C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.

  6. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    Therefore, if a drug has a bioavailability of 0.8 (or 80%) and it is administered in a dose of 100 mg, the equation will demonstrate the following: De = 0.8 × 100 mg = 80 mg. That is the 100 mg administered represents a blood plasma concentration of 80 mg that has the capacity to have a pharmaceutical effect.

  7. How Long Will It Take to Lose Weight on Metformin?

    www.aol.com/long-does-metformin-weight-loss...

    Among the 199 participants, 154 took a daily dose of up to 2,500mg of metformin for six months — the average metformin dose was 2,230mg daily. The remaining 45 participants weren’t treated ...

  8. Peak-to-trough ratio - Wikipedia

    en.wikipedia.org/wiki/Peak-to-trough_ratio

    Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...

  9. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years. Cadmium in bone has a biological half-life of about 30 years. Plutonium in bone has a biological half-life of about 100 years.

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