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  2. Granisetron - Wikipedia

    en.wikipedia.org/wiki/Granisetron

    Granisetron is a serotonin 5-HT 3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy and radiotherapy. Its main effect is to reduce the activity of the vagus nerve , which is a nerve that activates the vomiting center in the medulla oblongata .

  3. 5-HT3 antagonist - Wikipedia

    en.wikipedia.org/wiki/5-HT3_antagonist

    The first-generation 5-HT 3 receptor antagonist (ondansetron, dolasetron, granisetron, and tropisetron) have been the most important drugs in antiemetic therapy for emetogenic chemotherapy. They are especially effective in treating acute emesis, occurring in the first 24 hours following chemotherapy. [38]

  4. Serotonin receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Serotonin_receptor_antagonist

    They are efficacious in treating chemotherapy-induced emesis and postoperative nausea and vomiting. [1] They include, but are not limited to: Dolasetron; Granisetron; Ondansetron; Palonosetron; Tropisetron; Other 5-HT 3 antagonists have been considered for use in the treatment of irritable bowel syndrome: Alosetron; Cilansetron

  5. ProStrakan Launching SANCUSO (Granisetron Transdermal System ...

    www.aol.com/2013/09/30/prostrakan-launching...

    ProStrakan Launching SANCUSO (Granisetron Transdermal System) in European Union with 3M Drug Delivery Systems as Manufacturer First and only treatment targeting chemotherapy-induced nausea and ...

  6. A.P. Pharma Announces PDUFA Action Date for APF530 New ... - AOL

    www.aol.com/2012/10/16/ap-pharma-announces-pdufa...

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  7. Antiemetic - Wikipedia

    en.wikipedia.org/wiki/Antiemetic

    Granisetron (Kytril, Sancuso) can be administered in tablet (Kytril), oral solution (Kytril), injection (Kytril), or in a single transdermal patch to the upper arm (SANCUSO). Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection.

  8. Chemotherapy-induced nausea and vomiting - Wikipedia

    en.wikipedia.org/wiki/Chemotherapy-induced...

    These drugs block one or more of the nerve signals that cause nausea and vomiting. During the first 24 hours after chemotherapy, the most effective approach appears to be blocking the 5-HT 3 nerve signal. [10] Approved 5-HT 3 inhibitors include dolasetron (Anzemet), granisetron (Kytril, Sancuso), and ondansetron (Zofran). Their antiemetic ...

  9. 5-HT3 receptor - Wikipedia

    en.wikipedia.org/wiki/5-HT3_receptor

    However, with the discovery that the 5-HT 3 receptor plays a prominent role in chemotherapy- and radiotherapy-induced vomiting, and the concomitant development of selective 5-HT 3 receptor antagonists to suppress these side effects aroused intense interest from the pharmaceutical industry [2] [33] and therefore the identification of 5-HT 3 ...